RANK/RANKL pathway

The RANK/RANKL pathway is a crucial system in the body that regulates bone health. RANK is a protein found on the surface of certain cells called osteoclasts, which break down bone, while RANKL (RANK ligand) is a molecule that activates RANK. When RANKL binds to RANK, it stimulates osteoclasts to work more effectively, leading to bone resorption. This pathway is essential for maintaining bone density and balance, as too much activity can result in weakened bones, while too little can lead to bone accumulation. Understanding this pathway helps in addressing diseases like osteoporosis.