Receptor Activator of Nuclear Factor Kappa-Β

Receptor Activator of Nuclear Factor Kappa-Β (RANK) is a protein found on the surface of certain cells involved in bone health and immune system regulation. It interacts with a molecule called RANK Ligand (RANKL), which promotes the formation and activity of osteoclasts—cells that break down bone tissue. This process is essential for bone remodeling and calcium balance. An imbalance can lead to bone diseases like osteoporosis, where bones become weak. Understanding RANK helps in developing treatments to control bone loss and maintain healthy bones.