negative allosteric modulation

Negative allosteric modulation refers to the process by which a substance binds to a protein or receptor at a site distinct from its active site, altering the protein’s shape and function. This binding generally reduces the activity of the protein or receptor. In simpler terms, think of it like a dimmer switch for a light: instead of turning it off completely, the modulator adjusts the brightness, making it less active. This mechanism is often explored in drug development, as it can help control biological processes and potentially treat various conditions by fine-tuning cellular responses.