allosteric modulators

Allosteric modulators are substances that attach to a protein, such as a receptor, at a site different from where the main active molecule binds. This binding changes the protein's shape, altering how it responds to its usual signals. Positive allosteric modulators enhance the receptor's activity, making it respond more strongly, while negative ones decrease activity. They provide an additional layer of regulation, allowing fine-tuning of biological responses, which can be useful in developing targeted drugs with fewer side effects.