clonal evolution

Clonal evolution refers to the process where a population of cells, particularly in the context of cancer, undergoes genetic changes over time. These changes create different versions, or “clones,” of the original cells. Some clones may survive and thrive better than others due to mutations that help them evade the immune system or resist treatment. This ongoing evolution can lead to more aggressive cancer behavior and challenges in treatment, as the dominant clone may become resistant to therapies that were once effective, making it important to adapt treatment strategies accordingly.