Mitochondrial permeability transition pore

The mitochondrial permeability transition pore (mPTP) is a channel in the inner membrane of mitochondria, the energy-producing structures in cells. Under stress, such as injury or inflammation, this pore can open abnormally, allowing substances to flow across the membrane. This disrupts the balance of ions and molecules, leading to a loss of energy production and potentially triggering cell death. The mPTP plays a significant role in various diseases and is a key area of research for understanding cell health and developing treatments for conditions like heart disease and neurodegenerative disorders.