Hallmarks of Aging

The Hallmarks of Aging refer to key biological processes that contribute to the aging of cells and organisms. These include genomic instability (damage to DNA), telomere shortening (wear and tear on the ends of chromosomes), loss of proteostasis (difficulty in maintaining cellular proteins), and cellular senescence (cells that no longer divide). Other factors include reduced stem cell function, altered intercellular communication, and increased inflammation. Together, these changes lead to the decline of physiological functions, increasing susceptibility to diseases, and ultimately, a reduced lifespan. Understanding these hallmarks can help in exploring potential interventions for healthier aging.