B-cell malignancies

B-cell malignancies are cancers that originate in B-cells, which are important white blood cells that help the immune system fight infections. These malignancies include conditions like leukemia and lymphomas, where B-cells grow uncontrollably, forming tumors or spreading throughout the body. The abnormal B-cells may interfere with normal blood cell production and immune function, leading to symptoms such as fatigue, infections, and swollen lymph nodes. Treatment options vary and can include chemotherapy, radiation, targeted therapy, and immunotherapy, aimed at controlling the cancer and restoring healthy cell function.