Structure-activity relationship

A Structure-Activity Relationship (SAR) is a scientific concept that explores how the chemical structure of a compound affects its biological activity. Researchers study different chemical structures of similar compounds to see how changes—like the arrangement of atoms or the presence of certain functional groups—influence their effectiveness in interacting with biological targets, such as enzymes or receptors. Understanding SAR helps in drug development, as it allows scientists to modify compounds to enhance their desired effects and reduce side effects, ultimately leading to more effective and safer medications.