Lipinski's Rule of Five

Lipinski's Rule of Five is a guideline used in drug discovery to predict whether a chemical compound is likely to be an effective oral medication. It states that a compound should ideally have no more than one of the following: a molecular weight over 500 daltons, a calculated octanol-water partition coefficient (logP) greater than 5, more than 5 hydrogen bond donors, or more than 10 hydrogen bond acceptors. If a compound meets these criteria, it is more likely to be absorbed well in the body, increasing its potential as a viable drug candidate.