RANK/RANKL system

The RANK/RANKL system is crucial for bone health. RANK (Receptor Activator of Nuclear Factor Kappa-B) and RANKL (RANK Ligand) are proteins involved in bone remodeling. RANKL, produced by osteoblasts (bone-forming cells), binds to RANK on osteoclasts (bone-resorbing cells), activating them to break down bone. This process is essential for maintaining bone density and balance. When osteoclasts are activated, they help regulate calcium levels in the body. Dysregulation of this system can lead to bone disorders, such as osteoporosis, where bones become weak and fragile. Understanding RANK/RANKL can help in developing treatments for these conditions.