Molecular Mechanisms of Medulloblastoma

Medulloblastoma is a type of brain cancer that typically occurs in children. It arises from the abnormal growth of cells in the cerebellum, which controls movement and coordination. The cancer's development is linked to genetic mutations and changes in signaling pathways that regulate cell growth and division. Key mechanisms include the activation of oncogenes (genes that promote cell division) and the inactivation of tumor suppressor genes (which normally prevent cancer). These molecular changes lead to uncontrolled cell proliferation, forming tumors. Understanding these mechanisms helps in developing targeted treatments for medulloblastoma.