Janus kinases (JAKs)

Janus kinases (JAKs) are a group of enzymes that play a crucial role in the body's immune system and cell communication. They help transmit signals from various cytokines—proteins important for immune responses—into cells, influencing how they grow, divide, and respond to inflammation. By activating specific pathways, JAKs assist in regulating immune function and maintaining balance in response to infections or diseases. Abnormal JAK activity is linked to several disorders, leading to the development of targeted medications that inhibit JAKs, providing new treatment options for conditions like rheumatoid arthritis and certain cancers.