Fibroblast-like Synoviocytes

Fibroblast-like synoviocytes (FLS) are specialized cells found in the lining of joints, particularly in the synovial membrane. They play a crucial role in maintaining joint health by producing synovial fluid, which lubricates the joint and reduces friction during movement. FLS are also involved in the inflammatory response, helping to repair joint tissues when they are injured. However, in conditions like rheumatoid arthritis, these cells can become overactive, leading to excessive inflammation and damage to the joint, contributing to pain and stiffness. Understanding FLS helps researchers explore new treatments for joint-related diseases.