Cellular Biology of Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is a type of aggressive brain tumor characterized by rapidly multiplying cells. These cancerous cells evade normal growth controls, promoting inflammation and disrupting the surrounding brain tissue. GBM cells often develop resistance to treatments and can adapt their metabolism to thrive in low-oxygen environments. The tumor's complex structure includes diverse cell types, which complicates treatment strategies. Additionally, GBM can invade nearby healthy tissue, making complete surgical removal challenging. Due to its aggressive nature and resilience, GBM presents significant challenges for physicians and researchers in developing effective therapies.