MGMT (O6-Methylguanine-DNA Methyltransferase)

MGMT, or O6-Methylguanine-DNA Methyltransferase, is an enzyme that protects cells from DNA damage caused by harmful chemicals or radiation. It repairs specific types of mutations by removing abnormal methyl groups from the DNA base guanine, preventing errors during cell division. This process helps maintain genetic stability and can influence how effectively cancer treatments, like chemotherapy, work. If MGMT activity is high, cancer cells may resist treatment; if low, they might be more vulnerable. Overall, MGMT plays a critical role in repair mechanisms that keep our genetic information intact.