Amyloid Cascade Hypothesis
The Amyloid Cascade Hypothesis is a theory about Alzheimer’s disease, suggesting that the buildup of amyloid-beta protein in the brain triggers a series of events leading to brain cell damage and cognitive decline. This accumulation forms sticky plaques that disrupt communication between brain cells, leading to inflammation and further cell loss. Over time, these changes result in the symptoms of Alzheimer’s, such as memory loss and confusion. The hypothesis has guided research and development of potential treatments aiming to reduce amyloid-beta levels in hopes of slowing or preventing the disease.
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The amyloid cascade hypothesis suggests that the accumulation of a protein called amyloid-beta in the brain is a primary event that triggers Alzheimer's disease. This buildup forms sticky plaques between nerve cells, disrupting their communication. As a result, the brain starts to lose functional neurons, leading to cognitive decline and memory loss. The hypothesis posits that targeting amyloid-beta could help prevent or treat Alzheimer's disease, although research continues to explore other contributing factors and pathways involved in the disease's progression.