Gamma-Secretase

Gamma-secretase is a complex of proteins found in our cells that plays a crucial role in the process of cell signaling. It helps regulate the cleavage of certain membrane proteins, including the amyloid precursor protein (APP), which is significant in the context of Alzheimer's disease. When APP is cut by gamma-secretase, it can lead to the production of amyloid-beta peptides. These peptides can accumulate and form plaques in the brain, a hallmark of Alzheimer's. Therefore, gamma-secretase is an important target for research in understanding and treating neurodegenerative diseases.