Amyloid Precursor Protein (APP)

Amyloid Precursor Protein (APP) is a naturally occurring protein found mainly in the brain. Its primary role involves supporting neuron growth, repair, and communication. However, when APP is improperly processed, it can produce amyloid-beta fragments that tend to clump together, forming plaques linked to Alzheimer’s disease. These plaques interfere with brain cell function and are a hallmark of the disease’s progression. Understanding APP helps researchers explore how abnormal protein processing contributes to neurodegenerative conditions and may guide the development of treatments to prevent or reduce plaque formation.