Immune checkpoints

Immune checkpoints are regulatory molecules in the immune system that help maintain balance and prevent overactivity. They act like brakes, ensuring that immune responses do not become excessive, which could lead to damage to normal tissues. In cancer, some tumors exploit these checkpoints to evade detection and destruction by the immune system. Cancer treatments, known as immune checkpoint inhibitors, block these molecules, allowing the immune system to recognize and attack cancer cells more effectively. This strategy represents a significant advancement in cancer therapy, boosting the body's ability to fight tumors.