Chaperone-mediated autophagy

Chaperone-mediated autophagy (CMA) is a cellular process that helps maintain health by removing damaged proteins. In CMA, special proteins called chaperones recognize and escort malfunctioning proteins to lysosomes, the cell's waste disposal system. Once there, the proteins are broken down and recycled. This targeted approach allows cells to clean up without destroying whole organelles, ensuring that vital cellular functions continue smoothly. CMA plays a crucial role in adapting to stress and preventing diseases, including neurodegenerative disorders, by ensuring that cells efficiently manage their protein content.