HDACs (histone deacetylases)

Histone deacetylases (HDACs) are enzymes that play a crucial role in regulating gene expression within our cells. They remove acetyl groups from histones, the proteins around which DNA is wrapped. By doing so, HDACs make the DNA more tightly packed, which can prevent certain genes from being expressed. This process is essential for controlling various cellular functions, including growth, differentiation, and response to environmental signals. Abnormal HDAC activity is linked to diseases such as cancer, making them important targets for developing therapies. Understanding HDACs helps researchers explore how genes are regulated in health and disease.