Histone Deacetylases

Histone deacetylases (HDACs) are enzymes that regulate gene activity by removing acetyl groups from histones, the protein structures around which DNA is wrapped. When acetyl groups are removed, the DNA becomes more tightly coiled, making it less accessible for gene expression. This process influences how genes are turned on or off, impacting cell function and health. HDACs are important for maintaining normal cellular activities, and their imbalance has been linked to various diseases, including cancer and neurological disorders. Researchers study HDACs to develop therapies that can modulate their activity and restore proper gene regulation.