Guanine Nucleotide Exchange Factors (GEFs)

Guanine Nucleotide Exchange Factors (GEFs) are proteins that play a crucial role in cell signaling by activating small proteins called GTPases. These GTPases act like molecular switches, turning various cellular processes on or off. GEFs facilitate this activation by exchanging a molecule called GDP for GTP on the GTPase, effectively "turning it on." This process helps regulate many important functions in cells, including growth, movement, and communication. In summary, GEFs help control biological signals by manipulating the activity of these important molecular switches, influencing how cells respond to their environment.