Gastrointestinal Stromal Tumors (GIST)

Gastrointestinal Stromal Tumors (GISTs) are a type of tumor that originates in the digestive tract, often in the stomach or small intestine. They arise from specialized cells called interstitial cells of Cajal, which help regulate gut movement. GISTs can be benign (non-cancerous) or malignant (cancerous). Symptoms may include abdominal pain, nausea, or gastrointestinal bleeding. Treatment typically involves surgery to remove the tumor, and targeted therapies may be used for advanced cases. GISTs are often linked to mutations in the CD117 gene, which can help guide treatment decisions. Early diagnosis and tailored treatment improve outcomes.