PDGFRA (gene)

PDGFRA (Platelet-Derived Growth Factor Receptor Alpha) is a gene that provides instructions for making a protein involved in cell growth, division, and healing. This receptor is found on the surface of certain cells and interacts with growth factors to signal cells to grow and divide appropriately. Mutations or changes in the PDGFRA gene can lead to abnormal cell growth, which may contribute to certain tumors, like gastrointestinal stromal tumors (GISTs). Understanding PDGFRA helps researchers develop targeted treatments that can inhibit its activity in diseases caused by its malfunction.