KIT (gene)

The KIT gene provides instructions for making a protein called CD117 or stem cell factor receptor, which plays a key role in cell growth, development, and survival, especially in blood cells, melanocytes (skin pigment cells), and certain other tissues. It acts as a receptor on cell surfaces, helping cells respond to environmental signals. Mutations in the KIT gene can cause abnormal cell growth and are associated with certain cancers, including gastrointestinal stromal tumors (GISTs) and some types of leukemia. Understanding KIT helps in diagnosing these conditions and developing targeted treatments.