calcineurin

Calcineurin is an enzyme found in cells that plays a crucial role in regulating the immune system and other cellular processes. It activates a protein called NFAT, which influences the behavior of immune cells, especially T-cells, by promoting their activation and proliferation. This mechanism is important for the body's response to infections but can also lead to overactive immune responses in some conditions. Medications that inhibit calcineurin, like cyclosporine, are often used to prevent organ transplant rejection and treat autoimmune diseases by dampening the immune response.