Wolfram syndrome

Wolfram syndrome is a rare genetic disorder that typically appears in childhood or adolescence. It causes a combination of health problems, primarily affecting the nervous system and internal organs. Key features include diabetes insipidus (difficulty regulating water balance), diabetes mellitus (early-onset diabetes), optic atrophy (progressive vision loss), and deafness. It may also lead to neurological issues and hormone imbalances. The condition results from mutations in a specific gene that affects cell function, and it usually worsens over time. There is no cure, but managing symptoms and regular medical care can help improve quality of life.