TDP-43

TDP-43 is a protein found naturally in human cells that helps regulate the process of gene expression and manages how cells respond to stress. In certain neurological diseases like ALS (amyotrophic lateral sclerosis) and some forms of dementia, TDP-43 can misfold and form abnormal clumps inside nerve cells. These clumps disrupt normal cell functions and contribute to cell damage and death, leading to the symptoms seen in these conditions. Understanding TDP-43's role offers insights into disease mechanisms and potential targets for treatment.