Pathophysiology of Skeletal Metastasis

Skeletal metastasis occurs when cancer cells spread from their original site to the bones. This process involves cancer cells detaching from a tumor, entering the bloodstream, and settling in the bone tissue. Once there, they can disrupt normal bone metabolism, causing pain, weakening bones, and leading to complications like fractures. These abnormal cells can also provoke an inflammatory response, further contributing to bone damage. Overall, skeletal metastasis complicates the progression of cancer and significantly impacts a person's health and quality of life.