Hi-C

Hi-C is a scientific technique used to study the three-dimensional structure of DNA inside the cell nucleus. It works by capturing physical interactions between different parts of the genome that are close in space, even if they are far apart in the linear sequence. By crosslinking these interactions, fragmenting the DNA, and then sequencing the connected fragments, scientists can map how the genome folds and organizes itself. This helps researchers understand gene regulation, how parts of DNA communicate, and how the genome's structure influences cell function and development.