HER2-negative

HER2-negative refers to a status in certain types of cancer, particularly breast cancer, indicating that the cancer cells do not have an excess of the HER2 protein on their surface. HER2 is a specific protein that can promote cancer cell growth. If a tumor is HER2-negative, it typically does not respond to treatments that target HER2, such as trastuzumab (Herceptin). Understanding whether a cancer is HER2-negative is important for determining the most effective treatment options and predicting the likely behavior of the cancer.