Genetics of ALS

ALS (amyotrophic lateral sclerosis) genetics involve changes in specific genes that can disrupt how nerve cells in the brain and spinal cord function. Some gene mutations are inherited, meaning they run in families, increasing the risk of developing ALS. Others occur spontaneously. These genetic changes can affect proteins important for nerve health, leading to nerve cell deterioration and muscle weakness. While genetics play a significant role, most ALS cases are likely due to a combination of genetic and environmental factors. Understanding these genetic factors helps researchers explore potential treatments and early detection strategies.