Alfred G. Knudson (Geneticist)

Alfred G. Knudson was an influential American geneticist known for his groundbreaking work in cancer research. He is best recognized for proposing the "two-hit hypothesis," which explains how mutations in two copies of a gene can lead to cancer, particularly in hereditary forms. His research helped to illuminate the genetic basis of diseases and significantly advanced the understanding of how certain cancers develop. By identifying the genetic factors that contribute to cancer, Knudson's work paved the way for better diagnostic methods and treatments, impacting oncology and genetics profoundly. His contributions remain essential to modern cancer research.