George R. D. W. H. B. T. (G. R. D. W. H. B. T. Knudson)

George R. D. W. H. B. T. (G. R. D. W. H. B. T. Knudson) refers to a medical hypothesis known as the "Knudson hypothesis." It proposes that cancer develops through a process of accumulating genetic mutations, often requiring both "hits" or changes in tumor suppressor genes. This model explains why cancers may occur after a person inherits a faulty gene (a germline mutation) or develops mutations over time. It has significant implications for understanding cancer risk, inheritance, and the importance of genetic screening and targeted therapies.