X-linked OI

X-linked osteogenesis imperfecta (OI) is a genetic condition caused by a mutation on the X chromosome that affects collagen production, a key protein for strong bones. Since males have one X chromosome, a mutation often results in more severe symptoms, like fragile bones and frequent fractures. Females have two X chromosomes, so they may experience milder symptoms or be carriers without many issues. This inheritance pattern means the condition often runs differently in males and females. Overall, X-linked OI leads to bones that break easily, requiring careful management and medical support to improve quality of life.