Type I Collagen Deficiency

Type I collagen deficiency occurs when the body produces insufficient amounts of this protein, which provides strength and structure to bones, skin, tendons, and other tissues. This deficiency can lead to fragile bones that break easily (as seen in conditions like osteogenesis imperfecta), thin and fragile skin, and weak connective tissues. It results from genetic mutations affecting collagen production or structure, impairing the body's ability to maintain tissue integrity. This condition can vary in severity and may require medical management to protect bones and tissues from damage.