TLESR (Transient Lower Esophageal Sphincter Relaxation)

TLESR, or Transient Lower Esophageal Sphincter Relaxation, is a temporary relaxation of the muscle that controls food and acid movement from the stomach into the esophagus. Normally, this muscle stays tight to prevent reflux, but occasionally it relaxes spontaneously, allowing stomach contents—often acid—to flow back up. These brief relaxations are a primary cause of acid reflux and heartburn. TLESRs are a normal part of digestion, but when they occur frequently or excessively, they can lead to symptoms and complications related to gastroesophageal reflux disease (GERD).