The Glutamate Hypothesis

The Glutamate Hypothesis suggests that an imbalance in glutamate, a brain chemical involved in learning and communication between nerve cells, may contribute to schizophrenia. Normally, glutamate helps neurons send signals effectively, but in schizophrenia, these signals may become too weak or too strong, disrupting brain function. This imbalance can affect thinking, perception, and mood. Research indicates that targeting glutamate pathways might offer new treatments beyond traditional antipsychotics, aiming to restore proper communication in the brain and improve symptoms of the disorder.