SHANK3 (SH3 and multiple ankyrin repeat domains 3)

SHANK3 is a gene that produces a protein crucial for the proper functioning of synapses—the connections between nerve cells in the brain. This protein helps organize and stabilize these connections, which are essential for communication between neurons. Proper SHANK3 activity is important for normal brain development, learning, and behavior. Changes or mutations in the SHANK3 gene can disrupt these processes, potentially leading to neurological and developmental conditions such as autism spectrum disorder and intellectual disability. Overall, SHANK3 plays a vital role in mental health by supporting healthy brain connectivity.