SERPINA1 gene

The SERPINA1 gene provides instructions for making a protein called alpha-1 antitrypsin, which helps protect the lungs and liver from damage caused by enzymes that break down tissues. Variations in this gene can lead to lower levels or malfunctioning of the protein, increasing the risk of conditions like lung disease (such as emphysema) or liver problems. This gene is important for maintaining healthy tissue function, especially in the lungs. Mutations or inherited differences in SERPINA1 can significantly impact a person's respiratory and liver health.