Sequencing By Synthesis (SBS)

Sequencing By Synthesis (SBS) is a method used to determine the exact order of DNA bases (A, T, C, G) in a genetic sample. It works by first attaching DNA fragments to a surface and then adding labeled nucleotides, which are building blocks of DNA. When a nucleotide is incorporated into the growing DNA strand, it emits a detectable signal (like light), indicating which base was added. This process repeats, capturing signals at each step, allowing scientists to read the entire DNA sequence accurately. SBS is widely used in genome sequencing projects due to its precision and efficiency.