Senescence-accelerated mouse (SAM)

Senescence-accelerated mice (SAM) are a genetically modified strain of mice used in scientific research to study aging and age-related diseases. Unlike typical mice that show gradual aging, SAM mice experience accelerated aging, exhibiting signs of decline in physical and cognitive functions at a much younger age. Researchers use these mice to investigate the biological processes of aging, test potential anti-aging treatments, and better understand diseases like Alzheimer’s and other age-related conditions. Their rapid aging makes them valuable models for studying how aging affects health and for developing interventions to improve lifespan and quality of life.