RPE65 (retinal pigment epithelium-specific 65 kDa protein)

RPE65 is a protein found in the retinal pigment epithelium, a layer of cells supporting the retina in the eye. It plays a crucial role in the visual cycle by converting vitamin A into a form necessary for vision. Specifically, RPE65 helps regenerate the molecule that absorbs light, allowing us to see in different lighting conditions. Mutations in the RPE65 gene can disrupt this process, leading to vision problems or blindness, such as Leber congenital amaurosis and retinitis pigmentosa. Overall, RPE65 is essential for maintaining healthy, functioning photoreceptor cells necessary for sight.