Retinoblastoma protein (Rb)

The Retinoblastoma protein (Rb) is a crucial tumor suppressor involved in controlling cell growth and division. It acts as a gatekeeper, preventing cells from dividing too early or uncontrollably by regulating the activity of genes necessary for cell cycle progression. When functioning properly, Rb keeps cell growth in check; when it’s damaged or missing, cells can grow uncontrolled, leading to tumors like retinoblastoma, a type of eye cancer. Rb’s regulation is essential for maintaining healthy cell division and preventing cancer development.