RB pathway

The RB pathway involves the retinoblastoma protein (RB), which acts as a tumor suppressor by controlling cell division. When conditions signal that a cell should grow and divide, RB is modified, releasing its hold on genes that promote cell cycle progression. This allows the cell to proceed from a resting state to dividing. Proper regulation of RB ensures cells only divide when necessary, preventing uncontrolled growth that can lead to cancer. In essence, the RB pathway acts as a crucial brake, maintaining normal cell cycle control and preventing tumor formation.