polyenes

Polyenes are a class of antifungal medications that contain multiple long, alternating double bonds in their chemical structure. These compounds work by binding to ergosterol, a key component of fungal cell membranes, disrupting their integrity. This causes the membranes to become leaky, allowing essential ions and molecules to escape, which ultimately kills the fungus. Common polyenes include amphotericin B and nystatin. They are effective against serious fungal infections but can also affect human cell membranes, so their use requires careful monitoring.