Polg gene

The POLG gene provides instructions for making an enzyme called DNA polymerase gamma, which is essential for copying mitochondrial DNA—the small genetic material within energy-producing structures called mitochondria. Proper function of POLG is crucial for maintaining healthy mitochondria, which supply energy to cells. Mutations or errors in the POLG gene can disrupt this process, leading to mitochondrial diseases that often affect the brain, muscles, and other organs requiring high energy. In summary, POLG plays a key role in ensuring our cells generate and maintain the energy needed for normal function.