Pentavalent Antimonials

Pentavalent antimonials are a class of medications used primarily to treat leishmaniasis, a parasitic disease transmitted by sandflies. They contain compounds like meglumine antimoniate and sodium stibogluconate, which work by interfering with the parasite’s ability to survive and reproduce within the human host. Administered via injection, these drugs have been a mainstay in treatment for decades. While effective, they can cause side effects such as fever, muscle pain, and liver or kidney issues, so doctors monitor patients carefully during therapy. Their use has been crucial in controlling leishmaniasis in many parts of the world.